Genetic variability of respiratory syncytial virus A in hospitalized children in the last five consecutive winter seasons in Central Spain.
Identifieur interne : 000094 ( Main/Exploration ); précédent : 000093; suivant : 000095Genetic variability of respiratory syncytial virus A in hospitalized children in the last five consecutive winter seasons in Central Spain.
Auteurs : Ana Calder N [Espagne] ; Francisco Pozo [Espagne] ; Cristina Calvo [Espagne] ; Mluz García-García [Espagne] ; M Nica González-Esguevillas [Espagne] ; Mar Molinero [Espagne] ; Inmaculada Casas [Espagne]Source :
- Journal of medical virology [ 1096-9071 ] ; 2017.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Analyse de séquence d'ADN (MeSH), Enfant (MeSH), Enfant d'âge préscolaire (MeSH), Enquêtes et questionnaires (MeSH), Espagne (épidémiologie), Femelle (MeSH), Génotype (MeSH), Hospitalisation (MeSH), Humains (MeSH), Infections à virus respiratoire syncytial (virologie), Infections à virus respiratoire syncytial (épidémiologie), Mâle (MeSH), Nourrisson (MeSH), Protéines de fusion virale (génétique), Variation génétique (MeSH), Virus respiratoire syncytial humain (classification), Virus respiratoire syncytial humain (génétique), Virus respiratoire syncytial humain (isolement et purification), Épidémiologie moléculaire (MeSH).
- MESH :
- génétique : Protéines de fusion virale, Virus respiratoire syncytial humain.
- isolement et purification : Virus respiratoire syncytial humain.
- virologie : Infections à virus respiratoire syncytial.
- épidémiologie : Espagne, Infections à virus respiratoire syncytial.
- Adolescent, Analyse de séquence d'ADN, Enfant, Enfant d'âge préscolaire, Enquêtes et questionnaires, Femelle, Génotype, Hospitalisation, Humains, Mâle, Nourrisson, Variation génétique, Épidémiologie moléculaire.
English descriptors
- KwdEn :
- Adolescent (MeSH), Child (MeSH), Child, Preschool (MeSH), Female (MeSH), Genetic Variation (MeSH), Genotype (MeSH), Hospitalization (MeSH), Humans (MeSH), Infant (MeSH), Male (MeSH), Molecular Epidemiology (MeSH), Respiratory Syncytial Virus Infections (epidemiology), Respiratory Syncytial Virus Infections (virology), Respiratory Syncytial Virus, Human (classification), Respiratory Syncytial Virus, Human (genetics), Respiratory Syncytial Virus, Human (isolation & purification), Sequence Analysis, DNA (MeSH), Spain (epidemiology), Surveys and Questionnaires (MeSH), Viral Fusion Proteins (genetics).
- MESH :
- chemical , genetics : Viral Fusion Proteins.
- classification : Respiratory Syncytial Virus, Human.
- epidemiology : Respiratory Syncytial Virus Infections, Spain.
- genetics : Respiratory Syncytial Virus, Human.
- isolation & purification : Respiratory Syncytial Virus, Human.
- virology : Respiratory Syncytial Virus Infections.
- Adolescent, Child, Child, Preschool, Female, Genetic Variation, Genotype, Hospitalization, Humans, Infant, Male, Molecular Epidemiology, Sequence Analysis, DNA, Surveys and Questionnaires.
Abstract
Human respiratory syncytial virus group A (RSV-A) was detected in symptomatic hospital attended children in Central Spain for a continuous time period, September 2010 to April 2015. In order to accurately describe the epidemiology of this virus, the genetic diversity of the complete G gene and the clinical manifestations observed were jointly analyzed. Out of 3,011 respiratory specimens taken from 2,308 children, 640 were positive to RSV (21.3%) and 405 were RSV-A (63.2%). Complete G gene sequences of 166 randomly selected RSV-A virus identified NA1 and ON1 genotypes. In 2011-2012, ON1 emerged sporadically and become dominant in 2012-2013 with 38 cases (70%). In 2014-2015, all the 44 sequences contained the 72-nt duplication (100%). Clinical diagnosis of children with ON1 genotype were bronchiolitis in 55 (62.5%), recurrent wheezing or asthma exacerbations in 22 (25%), laryngotracheobronchitis in 3 (3.4%), and upper respiratory tract infections in eight. Results showed replacement and substitution of circulating NA1 genotype with the new ON1 genotype. Nevertheless, at this stage, none of the RSV-A genotypes identified have resulted in significant clinical differences. The amino acid composition of the complete G gene ON1 sequences demonstrated an accumulation of single changes not related with different clinical presentation. J. Med. Virol. 89:767-774, 2017. © 2016 Wiley Periodicals, Inc.
DOI: 10.1002/jmv.24703
PubMed: 27696460
Affiliations:
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Madrid</region></placeName></affiliation></author><author><name sortKey="Pozo, Francisco" sort="Pozo, Francisco" uniqKey="Pozo F" first="Francisco" last="Pozo">Francisco Pozo</name><affiliation wicri:level="3"><nlm:affiliation>Respiratory Virus and Influenza Unit, National Center for Microbiology, Instituto de Salud Carlos III, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Respiratory Virus and Influenza Unit, National Center for Microbiology, Instituto de Salud Carlos III, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Calvo, Cristina" sort="Calvo, Cristina" uniqKey="Calvo C" first="Cristina" last="Calvo">Cristina Calvo</name><affiliation wicri:level="3"><nlm:affiliation>Severo-Ochoa Hospital, Leganés, Madrid, Spain.</nlm:affiliation><country 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type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Child (MeSH)</term><term>Child, Preschool (MeSH)</term><term>Female (MeSH)</term><term>Genetic Variation (MeSH)</term><term>Genotype (MeSH)</term><term>Hospitalization (MeSH)</term><term>Humans (MeSH)</term><term>Infant (MeSH)</term><term>Male (MeSH)</term><term>Molecular Epidemiology (MeSH)</term><term>Respiratory Syncytial Virus Infections (epidemiology)</term><term>Respiratory Syncytial Virus Infections (virology)</term><term>Respiratory Syncytial Virus, Human (classification)</term><term>Respiratory Syncytial Virus, Human (genetics)</term><term>Respiratory Syncytial Virus, Human (isolation & purification)</term><term>Sequence Analysis, DNA (MeSH)</term><term>Spain (epidemiology)</term><term>Surveys and Questionnaires (MeSH)</term><term>Viral Fusion Proteins (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term><term>Analyse de séquence d'ADN (MeSH)</term><term>Enfant (MeSH)</term><term>Enfant d'âge préscolaire (MeSH)</term><term>Enquêtes et questionnaires (MeSH)</term><term>Espagne (épidémiologie)</term><term>Femelle (MeSH)</term><term>Génotype (MeSH)</term><term>Hospitalisation (MeSH)</term><term>Humains (MeSH)</term><term>Infections à virus respiratoire syncytial (virologie)</term><term>Infections à virus respiratoire syncytial (épidémiologie)</term><term>Mâle (MeSH)</term><term>Nourrisson (MeSH)</term><term>Protéines de fusion virale (génétique)</term><term>Variation génétique (MeSH)</term><term>Virus respiratoire syncytial humain (classification)</term><term>Virus respiratoire syncytial humain (génétique)</term><term>Virus respiratoire syncytial humain (isolement et purification)</term><term>Épidémiologie moléculaire (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Viral Fusion Proteins</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Respiratory Syncytial Virus, Human</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Respiratory Syncytial Virus Infections</term><term>Spain</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Respiratory Syncytial Virus, Human</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines de fusion virale</term><term>Virus respiratoire syncytial humain</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Respiratory Syncytial Virus, Human</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus respiratoire syncytial humain</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à virus respiratoire syncytial</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Respiratory Syncytial Virus Infections</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Espagne</term><term>Infections à virus respiratoire syncytial</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Genetic Variation</term><term>Genotype</term><term>Hospitalization</term><term>Humans</term><term>Infant</term><term>Male</term><term>Molecular Epidemiology</term><term>Sequence Analysis, DNA</term><term>Surveys and Questionnaires</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Analyse de séquence d'ADN</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Enquêtes et questionnaires</term><term>Femelle</term><term>Génotype</term><term>Hospitalisation</term><term>Humains</term><term>Mâle</term><term>Nourrisson</term><term>Variation génétique</term><term>Épidémiologie moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Human respiratory syncytial virus group A (RSV-A) was detected in symptomatic hospital attended children in Central Spain for a continuous time period, September 2010 to April 2015. In order to accurately describe the epidemiology of this virus, the genetic diversity of the complete G gene and the clinical manifestations observed were jointly analyzed. Out of 3,011 respiratory specimens taken from 2,308 children, 640 were positive to RSV (21.3%) and 405 were RSV-A (63.2%). Complete G gene sequences of 166 randomly selected RSV-A virus identified NA1 and ON1 genotypes. In 2011-2012, ON1 emerged sporadically and become dominant in 2012-2013 with 38 cases (70%). In 2014-2015, all the 44 sequences contained the 72-nt duplication (100%). Clinical diagnosis of children with ON1 genotype were bronchiolitis in 55 (62.5%), recurrent wheezing or asthma exacerbations in 22 (25%), laryngotracheobronchitis in 3 (3.4%), and upper respiratory tract infections in eight. Results showed replacement and substitution of circulating NA1 genotype with the new ON1 genotype. Nevertheless, at this stage, none of the RSV-A genotypes identified have resulted in significant clinical differences. The amino acid composition of the complete G gene ON1 sequences demonstrated an accumulation of single changes not related with different clinical presentation. J. Med. Virol. 89:767-774, 2017. © 2016 Wiley Periodicals, Inc.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27696460</PMID><DateCompleted><Year>2017</Year><Month>09</Month><Day>07</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>04</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1096-9071</ISSN><JournalIssue CitedMedium="Internet"><Volume>89</Volume><Issue>5</Issue><PubDate><Year>2017</Year><Month>05</Month></PubDate></JournalIssue><Title>Journal of medical virology</Title><ISOAbbreviation>J. Med. Virol.</ISOAbbreviation></Journal><ArticleTitle>Genetic variability of respiratory syncytial virus A in hospitalized children in the last five consecutive winter seasons in Central Spain.</ArticleTitle><Pagination><MedlinePgn>767-774</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/jmv.24703</ELocationID><Abstract><AbstractText>Human respiratory syncytial virus group A (RSV-A) was detected in symptomatic hospital attended children in Central Spain for a continuous time period, September 2010 to April 2015. In order to accurately describe the epidemiology of this virus, the genetic diversity of the complete G gene and the clinical manifestations observed were jointly analyzed. Out of 3,011 respiratory specimens taken from 2,308 children, 640 were positive to RSV (21.3%) and 405 were RSV-A (63.2%). Complete G gene sequences of 166 randomly selected RSV-A virus identified NA1 and ON1 genotypes. In 2011-2012, ON1 emerged sporadically and become dominant in 2012-2013 with 38 cases (70%). In 2014-2015, all the 44 sequences contained the 72-nt duplication (100%). Clinical diagnosis of children with ON1 genotype were bronchiolitis in 55 (62.5%), recurrent wheezing or asthma exacerbations in 22 (25%), laryngotracheobronchitis in 3 (3.4%), and upper respiratory tract infections in eight. Results showed replacement and substitution of circulating NA1 genotype with the new ON1 genotype. Nevertheless, at this stage, none of the RSV-A genotypes identified have resulted in significant clinical differences. The amino acid composition of the complete G gene ON1 sequences demonstrated an accumulation of single changes not related with different clinical presentation. J. Med. Virol. 89:767-774, 2017. © 2016 Wiley Periodicals, Inc.</AbstractText><CopyrightInformation>© 2016 Wiley Periodicals, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Calderón</LastName><ForeName>Ana</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Respiratory Virus and Influenza Unit, National Center for Microbiology, Instituto de Salud Carlos III, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pozo</LastName><ForeName>Francisco</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Respiratory Virus and Influenza Unit, National Center for Microbiology, Instituto de Salud Carlos III, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Calvo</LastName><ForeName>Cristina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Severo-Ochoa Hospital, Leganés, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>García-García</LastName><ForeName>Mluz</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Severo-Ochoa Hospital, Leganés, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>González-Esguevillas</LastName><ForeName>Mónica</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Respiratory Virus and Influenza Unit, National Center for Microbiology, Instituto de Salud Carlos III, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Molinero</LastName><ForeName>Mar</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Respiratory Virus and Influenza Unit, National Center for Microbiology, Instituto de Salud Carlos III, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Casas</LastName><ForeName>Inmaculada</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Respiratory Virus and Influenza Unit, National Center for Microbiology, Instituto de Salud Carlos III, Madrid, Spain.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>10</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Med Virol</MedlineTA><NlmUniqueID>7705876</NlmUniqueID><ISSNLinking>0146-6615</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C502275">G glycoprotein, Respiratory syncytial virus</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014760">Viral Fusion Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014644" MajorTopicYN="Y">Genetic Variation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005838" MajorTopicYN="Y">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006760" MajorTopicYN="Y">Hospitalization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017720" MajorTopicYN="N">Molecular Epidemiology</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018357" MajorTopicYN="N">Respiratory Syncytial Virus Infections</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018113" MajorTopicYN="N">Respiratory Syncytial Virus, Human</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="Y">classification</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017422" MajorTopicYN="N">Sequence Analysis, DNA</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N">Spain</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011795" MajorTopicYN="N">Surveys and Questionnaires</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014760" MajorTopicYN="N">Viral Fusion Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">G protein gene</Keyword><Keyword MajorTopicYN="Y">NA1 and ON1 genotypes</Keyword><Keyword MajorTopicYN="Y">pediatric bronquiolitis</Keyword><Keyword MajorTopicYN="Y">phylogenetic analysis</Keyword><Keyword MajorTopicYN="Y">respiratory syncytial virus A</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>09</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>10</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>9</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>10</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27696460</ArticleId><ArticleId IdType="doi">10.1002/jmv.24703</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li></country><region><li>Communauté de Madrid</li></region><settlement><li>Madrid</li></settlement></list><tree><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Calder N, Ana" sort="Calder N, Ana" uniqKey="Calder N A" first="Ana" last="Calder N">Ana Calder N</name></region><name sortKey="Calvo, Cristina" sort="Calvo, Cristina" uniqKey="Calvo C" first="Cristina" last="Calvo">Cristina Calvo</name><name sortKey="Casas, Inmaculada" sort="Casas, Inmaculada" uniqKey="Casas I" first="Inmaculada" last="Casas">Inmaculada Casas</name><name sortKey="Garcia Garcia, Mluz" sort="Garcia Garcia, Mluz" uniqKey="Garcia Garcia M" first="Mluz" last="García-García">Mluz García-García</name><name sortKey="Gonzalez Esguevillas, M Nica" sort="Gonzalez Esguevillas, M Nica" uniqKey="Gonzalez Esguevillas M" first="M Nica" last="González-Esguevillas">M Nica González-Esguevillas</name><name sortKey="Molinero, Mar" sort="Molinero, Mar" uniqKey="Molinero M" first="Mar" last="Molinero">Mar Molinero</name><name sortKey="Pozo, Francisco" sort="Pozo, Francisco" uniqKey="Pozo F" first="Francisco" last="Pozo">Francisco Pozo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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